Details of the Target

General Information of Target

Target ID LDTP03134
Target Name Biglycan (BGN)
Gene Name BGN
Gene ID 633
Synonyms
SLRR1A; Biglycan; Bone/cartilage proteoglycan I; PG-S1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYS
AMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALV
LVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFS
GLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLTGIPKDLPETLNELHLDHNK
IQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLARVPSGLPDLK
LLQVVYLHSNNITKVGVNDFCPMGFGVKRAYYNGISLFNNPVPYWEVQPATFRCVTDRLA
IQFGNYKK
Target Type
Literature-reported
Target Bioclass
Other
Family
Small leucine-rich proteoglycan (SLRP) family, SLRP class I subfamily
Subcellular location
Secreted, extracellular space, extracellular matrix
Function May be involved in collagen fiber assembly.
TTD ID
T26304
Uniprot ID
P21810
DrugMap ID
TT0JPVF
Ensemble ID
ENST00000331595.9
HGNC ID
HGNC:1044

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C321(4.62)  LDD3342  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 AGS C187(1.63)  LDD2263  [1]
 LDCM0023  KB03 AN3-CA C187(1.45)  LDD2681  [1]
 LDCM0024  KB05 NCI-H1155 C321(4.62)  LDD3342  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840