Details of the Target
General Information of Target
| Target ID | LDTP03126 | |||||
|---|---|---|---|---|---|---|
| Target Name | C5a anaphylatoxin chemotactic receptor 1 (C5AR1) | |||||
| Gene Name | C5AR1 | |||||
| Gene ID | 728 | |||||
| Synonyms |
C5AR; C5R1; C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR; CD antigen CD88 |
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| 3D Structure | ||||||
| Sequence |
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVW
VTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNM YASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREE YFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKT LKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIY VVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV |
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| Target Type |
Successful
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| Target Bioclass |
GPCR
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| Family |
G-protein coupled receptor 1 family
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| Subcellular location |
Cell membrane
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| Function |
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production.
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| TTD ID | ||||||
| Uniprot ID | ||||||
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| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C188(7.58) | LDD3366 | [1] | |
Competitor(s) Related to This Target