Details of the Target

General Information of Target

Target ID LDTP03123
Target Name Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (GPD1)
Gene Name GPD1
Gene ID 2819
Synonyms
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic; GPD-C; GPDH-C; EC 1.1.1.8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASKKVCIVGSGNWGSAIAKIVGGNAAQLAQFDPRVTMWVFEEDIGGKKLTEIINTQHEN
VKYLPGHKLPPNVVAVPDVVQAAEDADILIFVVPHQFIGKICDQLKGHLKANATGISLIK
GVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEKFCETTIGCKDPAQGQLLKEL
MQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAK
LFCSGPVSSATFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKELLNGQKLQGP
ETARELYSILQHKGLVDKFPLFMAVYKVCYEGQPVGEFIHCLQNHPEHM
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
NAD-dependent glycerol-3-phosphate dehydrogenase family
Subcellular location
Cytoplasm
Function Has glycerol-3-phosphate dehydrogenase activity.
TTD ID
T77721
Uniprot ID
P21695
DrugMap ID
TTKTEAH
Ensemble ID
ENST00000301149.8
HGNC ID
HGNC:4455

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
JURKAT SNV: p.A274V .
NCIH1666 Deletion: p.F252VfsTer6 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
Probe 1
 Probe Info  		Y63(31.73)  LDD3495  [2]
HHS-465
 Probe Info  		Y63(9.25)  LDD2237  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM25C (FAM25C) FAM25 family B3EWG5

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Metformin Small molecular drug DB00331
Nadh Small molecular drug DB00157

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.