Details of the Target

General Information of Target

Target ID LDTP03115
Target Name Alanine--glyoxylate aminotransferase (AGXT)
Gene Name AGXT
Gene ID 189
Synonyms
AGT1; SPAT; Alanine--glyoxylate aminotransferase; AGT; EC 2.6.1.44; Serine--pyruvate aminotransferase; SPT; EC 2.6.1.51
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEI
KEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIG
ARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLL
LVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSF
YLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHG
RLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLR
IGLLGCNATRENVDRVTEALRAALQHCPKKKL
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Class-V pyridoxal-phosphate-dependent aminotransferase family
Subcellular location
Peroxisome
Function
Peroxisomal aminotransferase that catalyzes the transamination of glyoxylate to glycine and contributes to the glyoxylate detoxification. Also catalyzes the transamination between L-serine and pyruvate and contributes to gluconeogenesis from the L-serine metabolism.
TTD ID
T06365
Uniprot ID
P21549
DrugMap ID
TTF5NVW
Ensemble ID
ENST00000307503.4
HGNC ID
HGNC:341
ChEMBL ID
CHEMBL5169121

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C366(0.96)  LDD3351  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Hep 3B2.1-7 C387(0.93); C366(0.99)  LDD2353  [2]
 LDCM0023  KB03 Hep 3B2.1-7 C387(0.82); C366(0.92)  LDD2770  [2]
 LDCM0024  KB05 NCI-H196 C366(0.96)  LDD3351  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Class V-like SAM-binding methyltransferase superfamily Q9NQX0
Alanine--glyoxylate aminotransferase (AGXT) Class-V pyridoxal-phosphate-dependent aminotransferase family P21549
Group 10 secretory phospholipase A2 (PLA2G10) Phospholipase A2 family O15496
Protein farnesyltransferase subunit beta (FNTB) Protein prenyltransferase subunit beta family P49356
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Basic leucine zipper transcriptional factor ATF-like 3 (BATF3) BZIP family Q9NR55
Protein FosB (FOSB) BZIP family P53539
DNA-binding protein RFX6 (RFX6) RFX family Q8HWS3
Other
Click To Hide/Show 21 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1-like (ATXN1L) ATXN1 family P0C7T5
Cilia- and flagella-associated protein 68 (CFAP68) CFAP68 family Q9H5F2
Cysteine-rich hydrophobic domain-containing protein 2 (CHIC2) CHIC family Q9UKJ5
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cuticular Ha7 (KRT37) Intermediate filament family O76014
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 12-3 (KRTAP12-3) KRTAP type 12 family P60328
Keratin-associated protein 3-1 (KRTAP3-1) KRTAP type 3 family Q9BYR8
Keratin-associated protein 8-1 (KRTAP8-1) KRTAP type 8 family Q8IUC2
Keratin-associated protein 9-2 (KRTAP9-2) KRTAP type 9 family Q9BYQ4
Protein Mis18-beta (OIP5) Mis18 family O43482
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Leupaxin (LPXN) Paxillin family O60711
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) TTC19 family Q6DKK2
Four and a half LIM domains protein 5 (FHL5) . Q5TD97
MORN repeat-containing protein 5 (MORN5) . Q5VZ52
Pleckstrin homology domain-containing family G member 7 (PLEKHG7) . Q6ZR37
Trafficking protein particle complex subunit 14 (TRAPPC14) . Q8WVR3

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Glycine Small molecular drug DB00145
Pyridoxal Phosphate Small molecular drug DB00114
Investigative
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alanine Small molecular drug DB00160
Aminooxyacetic Acid Small molecular drug DB02079
Serine Small molecular drug DB00133
4-(2-aminophenyl)-4-oxobutanoic Acid . DB08060
N(6)-(Pyridoxal Phosphate)-l-lysine . DB04083

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840