Details of the Target
General Information of Target
| Target ID | LDTP03087 | |||||
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| Target Name | C4b-binding protein beta chain (C4BPB) |
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| Gene Name | C4BPB | |||||
| Gene ID | 725 | |||||
| Synonyms |
C4b-binding protein beta chain |
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| 3D Structure | ||||||
| Sequence |
MFFWCACCLMVAWRVSASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKT
LFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQ CLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCV DGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSL ELKKAELKAKLL |
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| Target Bioclass |
Other
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| Subcellular location |
Secreted
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| Function |
Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
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Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C202(1.64) | LDD3424 | [1] | |
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NAIA_4 Probe Info |
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N.A. | LDD2226 | [2] | |
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IPM Probe Info |
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N.A. | LDD0147 | [3] | |
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TFBX Probe Info |
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N.A. | LDD0148 | [3] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
References