Details of the Target

General Information of Target

Target ID	LDTP03086
Target Name	Collagen alpha-1(IX) chain (COL9A1)
Gene Name	COL9A1
Gene ID	1297
Synonyms	Collagen alpha-1(IX) chain
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MKTCWKIPVFFFVCSFLEPWASAAVKRRPRFPVNSNSNGGNELCPKIRIGQDDLPGFDLI SQFQVDKAASRRAIQRVVGSATLQVAYKLGNNVDFRIPTRNLYPSGLPEEYSFLTTFRMT GSTLKKNWNIWQIQDSSGKEQVGIKINGQTQSVVFSYKGLDGSLQTAAFSNLSSLFDSQW HKIMIGVERSSATLFVDCNRIESLPIKPRGPIDIDGFAVLGKLADNPQVSVPFELQWMLI HCDPLRPRRETCHELPARITPSQTTDERGPPGEQGPPGPPGPPGVPGIDGIDGDRGPKGP PGPPGPAGEPGKPGAPGKPGTPGADGLTGPDGSPGSIGSKGQKGEPGVPGSRGFPGRGIP GPPGPPGTAGLPGELGRVGPVGDPGRRGPPGPPGPPGPRGTIGFHDGDPLCPNACPPGRS GYPGLPGMRGHKGAKGEIGEPGRQGHKGEEGDQGELGEVGAQGPPGAQGLRGITGIVGDK GEKGARGLDGEPGPQGLPGAPGDQGQRGPPGEAGPKGDRGAEGARGIPGLPGPKGDTGLP GVDGRDGIPGMPGTKGEPGKPGPPGDAGLQGLPGVPGIPGAKGVAGEKGSTGAPGKPGQM GNSGKPGQQGPPGEVGPRGPQGLPGSRGELGPVGSPGLPGKLGSLGSPGLPGLPGPPGLP GMKGDRGVVGEPGPKGEQGASGEEGEAGERGELGDIGLPGPKGSAGNPGEPGLRGPEGSR GLPGVEGPRGPPGPRGVQGEQGATGLPGVQGPPGRAPTDQHIKQVCMRVIQEHFAEMAAS LKRPDSGATGLPGRPGPPGPPGPPGENGFPGQMGIRGLPGIKGPPGALGLRGPKGDLGEK GERGPPGRGPNGLPGAIGLPGDPGPASYGRNGRDGERGPPGVAGIPGVPGPPGPPGLPGF CEPASCTMQAGQRAFNKGPDP
Target Bioclass	Other
Family	Fibril-associated collagens with interrupted helices (FACIT) family
Subcellular location	Secreted, extracellular space, extracellular matrix
Function	Structural component of hyaline cartilage and vitreous of the eye.
Uniprot ID	P20849
Ensemble ID	ENST00000320755.12
HGNC ID	HGNC:2217

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
CAL148	SNV: p.G529D	.
CORL88	SNV: p.S173F	.
DAOY	SNV: p.Q738H	.
HCT116	SNV: p.G281A	.
ICC4	SNV: p.I7F	.
IGR1	SNV: p.P803S	.
IPC298	SNV: p.P723S	.
KPL1	SNV: p.G364C	.
KYSE180	SNV: p.P498S	.
LOXIMVI	SNV: p.P498S	.
MCF7	SNV: p.G364C	.
MEWO	SNV: p.G610R; p.G658E; p.G676D; p.G739R; p.P825S	.
NCIH1155	SNV: p.A904T	.
NCIH716	SNV: p.G553Ter	.
OPM2	SNV: p.K126N	.
OZ	Substitution: p.P465K	.
P31FUJ	SNV: p.G311E	.
RKO	SNV: p.P732S	.
SBC5	SNV: p.G382V	.
SNU1079	SNV: p.I212V	.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
CY-1 Probe Info			W128(0.00); W131(0.00); Q132(0.00); Q134(0.00)	LDD0246	[1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Kallikrein-6 (KLK6)				Peptidase S1 family	Q92876

Transporter and channel

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Alpha-crystallin A chain (CRYAA)				Small heat shock protein (HSP20) family	P02489

References

1	Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.