Details of the Target

General Information of Target

Target ID LDTP03085
Target Name Alpha-1-antitrypsin-related protein (SERPINA2)
Gene Name SERPINA2
Gene ID 390502
Synonyms
ARGS; ATR; PIL; SERPINA2P; Alpha-1-antitrypsin-related protein; AAT-related protein; Protease inhibitor 1-like; Serpin A2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPFSVSWGILLLAGLCCLVPSSLVEDPQEDAAQKTDTSHHDQGDWEDLACQKISYNVTDL
AFDLYKELADLSQTSNVLVTPTSVAMAFAMLSLGTKADTRTEILEGLNVNLTETPEAKIH
ECFQQVLQALSRPDTRLQLTTGSSLFVNKSMKLVDTFLEDTKKLYHSEASSINFRDTEEA
KEQINNYVEKRTGRKVVDLVKHLKKDTSLALVDYISFHGKWKDKFKAEHIMVEGFHVDDK
TIIRVPMINHLGRFDIHRDRELSSWVLAQHYVGNATAFFILPDPKKMWQLEEKLTYSHLE
NIQRAFDIRSINLHFPKLSISGTYKLKRVLRNLGITKIFSNEADLSGVSQEAPLKLSKAV
HVAVLTIDEKGTEATGAPHLEEKAWSKYQTVMFNRPFLVIIKDDITNFPLFIGKVVNPTQ
K
Target Bioclass
Other
Family
Serpin family
Subcellular location
Endoplasmic reticulum
Function Putative serine protease inhibitor.
Uniprot ID
P20848
Ensemble ID
ENST00000616052.3
HGNC ID
HGNC:8985
ChEMBL ID
CHEMBL4879431

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K117(3.23)  LDD0277  [1]
DBIA
 Probe Info  		C1343(2.24); C790(3.12)  LDD3310  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C1343(1.46)  LDD2243  [2]
 LDCM0023  KB03 42-MG-BA C1343(2.53)  LDD2661  [2]
 LDCM0024  KB05 COLO792 C1343(2.24); C790(3.12)  LDD3310  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840