Details of the Target

General Information of Target

Target ID LDTP03069
Target Name Granzyme H (GZMH)
Gene Name GZMH
Gene ID 2999
Synonyms
CGL2; CTSGL2; Granzyme H; EC 3.4.21.-; CCP-X; Cathepsin G-like 2; CTSGL2; Cytotoxic T-lymphocyte proteinase; Cytotoxic serine protease C; CSP-C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL
TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW
TTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNY
SRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIK
RTMKRL
Target Bioclass
Enzyme
Family
Peptidase S1 family, Granzyme subfamily
Subcellular location
Cytolytic granule
Function
Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.
Uniprot ID
P20718
Ensemble ID
ENST00000216338.9
HGNC ID
HGNC:4710

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.N104T .
IM95 SNV: p.P205A .
MEWO SNV: p.A118T .
RKO SNV: p.P205A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C170, C172(8.16)  LDD1705  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0024  KB05 T cell C170, C172(8.16)  LDD1705  [1]

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.