Details of the Target

General Information of Target

Target ID LDTP03068
Target Name Aromatic-L-amino-acid decarboxylase (DDC)
Gene Name DDC
Gene ID 1644
Synonyms
AADC; Aromatic-L-amino-acid decarboxylase; AADC; EC 4.1.1.28; DOPA decarboxylase; DDC
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNASEFRRRGKEMVDYMANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV
EKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD
WLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM
EKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV
ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN
PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL
KMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN
EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE
Target Type
Successful
Target Bioclass
Enzyme
Family
Group II decarboxylase family
Function Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin.
TTD ID
T62193
Uniprot ID
P20711
DrugMap ID
TTN451K
Ensemble ID
ENST00000357936.9
HGNC ID
HGNC:2719
ChEMBL ID
CHEMBL1843

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.L153P .
DU145 SNV: p.Q383R .
ICC10 SNV: p.Q425Ter .
LNCaP clone FGC SNV: p.V240F .
MEWO SNV: p.P301L
Substitution: .		 .
NCIH1793 SNV: p.A45V .
SNGM Deletion: p.I433SfsTer98 .
SW1783 SNV: p.A231V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C311(1.97)  LDD3340  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Calu-1 C451(1.89)  LDD2292  [2]
 LDCM0023  KB03 Calu-1 C451(3.17)  LDD2709  [2]
 LDCM0024  KB05 NB1 C311(1.97)  LDD3340  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Androgen receptor (AR) Nuclear hormone receptor family P10275

The Drug(s) Related To This Target

Approved
Click To Hide/Show 10 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amantadine Small molecular drug DB00915
Carbidopa Small molecular drug D0P7JZ
Cycloserine Small molecular drug DB00260
Droxidopa Small molecular drug DB06262
Flupentixol Small molecular drug DB00875
Levodopa Small molecular drug DB01235
Methyldopa Small molecular drug DB00968
Pyridoxal Phosphate Small molecular drug DB00114
Tryptophan Small molecular drug DB00150
Vitamin B6 Small molecular drug D07MUN
Phase 3
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Benserazide Small molecular drug D0X8ED
Patrome . D03QFN
Phase 2
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gt-aadc Gene therapy DX9KC2
Oxb-102 Gene therapy D72UDH
Vy-aadc Gene therapy DH1W0G
Av-201 . D02ITL
Prosavin . D05ICS
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
3-hydroxybenzylhydrazine Small molecular drug D0P9BM
Noradrenalone (Arterenone) Small molecular drug D0IB8N

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840