Details of the Target

General Information of Target

Target ID LDTP03066
Target Name Integrin alpha-L (ITGAL)
Gene Name ITGAL
Gene ID 3683
Synonyms
CD11A; Integrin alpha-L; CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; CD antigen CD11a
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGA
PGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCD
QNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMK
DVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYV
ATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLH
KFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSR
GHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLL
ASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLI
GAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVA
VGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVA
VGAESQMIVLSSRPVVDMVTLMSFSPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLI
PQFQGRLVANLTYTLQLDGHRTRRRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQD
LISPINVSLNFSLWEEEGTPRDQRAQGKDIPPILRPSLHSETWEIPFEKNCGEDKKCEAN
LRVSFSPARSRALRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQ
IPVSCEELPEESRLLSRALSCNVSSPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTC
NNEDSDLLEDNSATTIIPILYPINILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPS
IHDHNIPTLEAVVGVPQPPSEGPITHQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFR
CPVVFRQEILVQVIGTLELVGEIEASSMFSLCSSLSISFNSSKHFHLYGSNASLAQVVMK
VDVVYEKQMLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDS
EQLASGQEAGDPGCLKPLHEKDSESGGGKD
Target Type
Successful
Target Bioclass
Transporter and channel
Family
Integrin alpha chain family
Subcellular location
Cell membrane
Function
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.
TTD ID
T35640
Uniprot ID
P20701
DrugMap ID
TT48WR6
Ensemble ID
ENST00000356798.11
HGNC ID
HGNC:6148
ChEMBL ID
CHEMBL1803

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.E243D .
CCK81 SNV: p.A41T .
EFO27 Deletion: p.P715RfsTer15
SNV: p.V601M		 .
HEC1 SNV: p.A543G .
HS578T SNV: p.D538E .
JURKAT Deletion: p.D890TfsTer9
Insertion: p.L827TfsTer13
SNV: p.T7N;p.I917T;p.S980N;p.Q1147Ter		 .
LS180 Deletion: p.P825RfsTer11 .
MELJUSO SNV: p.Q447K .
MFE296 Deletion: p.S562VfsTer8 .
MFE319 SNV: p.R857G .
MOLT4 SNV: p.S88F; p.S422Ter IA-alkyne    Probe Info 
NCIH358 SNV: p.G457S .
RKO SNV: p.D207N .
RL952 SNV: p.G1115S .
TGBC1TKB SNV: p.D269Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y332(10.91)  LDD0260  [1]
DBIA
 Probe Info  		C929(3.44); C150(4.39); C111(1.73)  LDD3333  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C777(0.00); C150(0.00); C111(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C111(0.00); C777(0.00); C129(0.00); C119(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C150(0.00); C845(0.00)  LDD0037  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 T cell C119, C129(9.17)  LDD1707  [4]
 LDCM0023  KB03 CMK C929(1.73)  LDD2719  [2]
 LDCM0024  KB05 MOLM-13 C929(3.44); C150(4.39); C111(1.73)  LDD3333  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor-type tyrosine-protein phosphatase C (PTPRC) Protein-tyrosine phosphatase family P08575
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Intercellular adhesion molecule 1 (ICAM1) ICAM family P05362

The Drug(s) Related To This Target

Approved
Click To Hide/Show 8 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Efalizumab Antibody D03SGR
Antithymocyte Immunoglobulin (Rabbit) BiotechDrug DB00098
Lifitegrast Small molecular drug D0Q9EV
Lifitegrast Small molecular drug DB11611
Lovastatin Small molecular drug DB00227
Pitavastatin Small molecular drug DB08860
Rosuvastatin Small molecular drug DB01098
Simvastatin Small molecular drug DB00641
Preclinical
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cytolin Antibody D03RYN
Investigative
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
A-286982 Small molecular drug D07XCA
Leukotoxin Small molecular drug D00FIV
Lfa703 Small molecular drug D0W3WW
(S)-2-((S)-3-isobutyl-25-dioxo-4-quinolin-3-ylmethyl-[14]Diazepan-1yl)-n-methyl-3-naphtalen-2-yl-propionamide . DB04724
1-acetyl-4-(4-{4-[(2-ethoxyphenyl)Thio]-3-nitrophenyl}Pyridin-2-yl)Piperazine . DB02177
3-({4-[(1e)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-23-bis(Trifluoromethyl)Phenyl}Sulfanyl)Aniline . DB07486
7a-[(4-cyanophenyl)Methyl]-6-(35-dichlorophenyl)-5-oxo-2357a-tetrahydro-1h-pyrrolo[12-a]Pyrrole-7-carbonitrile . DB06972
Discontinued
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bms-587101 . D0GT8W
Ic-747 . D0W7GH

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.