Details of the Target
General Information of Target
| Target ID | LDTP03058 | |||||
|---|---|---|---|---|---|---|
| Target Name | Interferon-induced GTP-binding protein Mx2 (MX2) | |||||
| Gene Name | MX2 | |||||
| Gene ID | 4600 | |||||
| Synonyms |
Interferon-induced GTP-binding protein Mx2; Interferon-regulated resistance GTP-binding protein MxB; Myxovirus resistance protein 2; p78-related protein |
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| 3D Structure | ||||||
| Sequence |
MSKAHKPWPYRRRSQFSSRKYLKKEMNSFQQQPPPFGTVPPQMMFPPNWQGAEKDAAFLA
KDFNFLTLNNQPPPGNRSQPRAMGPENNLYSQYEQKVRPCIDLIDSLRALGVEQDLALPA IAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKQPCEAWAGRISYRNTELEL QDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDLTIIDLPGITRVAVDNQPRD IGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHEVDPEGDRTIGILTKPDLMD RGTEKSVMNVVRNLTYPLKKGYMIVKCRGQQEITNRLSLAEATKKEITFFQTHPYFRVLL EEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRESHQKATEELRRCGADIPSQEADKMF FLIEKIKMFNQDIEKLVEGEEVVRENETRLYNKIREDFKNWVGILATNTQKVKNIIHEEV EKYEKQYRGKELLGFVNYKTFEIIVHQYIQQLVEPALSMLQKAMEIIQQAFINVAKKHFG EFFNLNQTVQSTIEDIKVKHTAKAENMIQLQFRMEQMVFCQDQIYSVVLKKVREEIFNPL GTPSQNMKLNSHFPSNESSVSSFTEIGIHLNAYFLETSKRLANQIPFIIQYFMLRENGDS LQKAMMQILQEKNRYSWLLQEQSETATKRRILKERIYRLTQARHALCQFSSKEIH |
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| Target Bioclass |
Transporter and channel
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| Family |
TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family
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| Subcellular location |
Cytoplasm
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| Function |
Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| CHL1 | SNV: p.R690K | . | |||
| IGROV1 | SNV: p.R108L | . | |||
| MCC13 | SNV: p.Q383Ter; p.G408E | . | |||
| MKN1 | SNV: p.K608R | DBIA Probe Info | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
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C52(2.90) | LDD3312 | [1] | |
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IA-alkyne Probe Info |
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C707(6.47) | LDD1703 | [2] | |
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W1 Probe Info |
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N.A. | LDD0236 | [3] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Enzyme
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Histone-lysine N-methyltransferase EHMT2 (EHMT2) | Histone-lysine methyltransferase family | Q96KQ7 | |||
| E3 SUMO-protein ligase PIAS2 (PIAS2) | PIAS family | O75928 | |||
Other
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| ATR-interacting protein (ATRIP) | ATRIP family | Q8WXE1 | |||
References