Details of the Target

General Information of Target

Target ID LDTP03038
Target Name Tryptase beta-2 (TPSB2)
Gene Name TPSB2
Gene ID 64499
Synonyms
TPS2; Tryptase beta-2; Tryptase-2; EC 3.4.21.59; Tryptase II
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVRDRYWMHFCG
GSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGA
DIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKV
PIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAG
VVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
Target Bioclass
Enzyme
Family
Peptidase S1 family, Tryptase subfamily
Subcellular location
Secreted
Function Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity.
Uniprot ID
P20231
Ensemble ID
ENST00000606293.5
HGNC ID
HGNC:14120
ChEMBL ID
CHEMBL4523196

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C188(1.87)  LDD3335  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 CMK C188(1.60)  LDD2302  [1]
 LDCM0023  KB03 CMK C188(1.95)  LDD2719  [1]
 LDCM0024  KB05 MONO-MAC-6 C188(1.87)  LDD3335  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840