Details of the Target
General Information of Target
| Target ID | LDTP03021 | |||||
|---|---|---|---|---|---|---|
| Target Name | Follistatin (FST) |
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| Gene Name | FST | |||||
| Gene ID | 10468 | |||||
| Synonyms |
Follistatin; FS; Activin-binding protein |
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| 3D Structure | ||||||
| Sequence |
MVRARHQPGGLCLLLLLLCQFMEDRSAQAGNCWLRQAKNGRCQVLYKTELSKEECCSTGR
LSTSWTEEDVNDNTLFKWMIFNGGAPNCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAP DCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTCRDVFCPGSSTCV VDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCI KAKSCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEA ACSSGVLLEVKHSGSCNSISEDTEEEEEDEDQDYSFPISSILEW |
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| Target Type |
Literature-reported
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| Target Bioclass |
Other
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| Subcellular location |
Secreted
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| Function | Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). | |||||
| TTD ID | ||||||
| Uniprot ID | ||||||
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| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C132(3.82) | LDD3365 | [1] | |
Competitor(s) Related to This Target