Details of the Target

General Information of Target

Target ID LDTP03020
Target Name Neutrophil cytosol factor 2 (NCF2)
Gene Name NCF2
Gene ID 4688
Synonyms
NOXA2; P67PHOX; Neutrophil cytosol factor 2; NCF-2; 67 kDa neutrophil oxidase factor; NADPH oxidase activator 2; Neutrophil NADPH oxidase factor 2; p67-phox
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAF
TRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFA
CEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPVG
KLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRAL
EGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELR
IHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKY
TVVMKTQPGLPYSQVRDMVSKKLELRLEHTKLSYRPRDSNELVPLSEDSMKDAWGQVKNY
CLTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQE
GDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV
Target Bioclass
Other
Family
NCF2/NOXA1 family
Subcellular location
Cytoplasm
Function NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
Uniprot ID
P19878
Ensemble ID
ENST00000367535.8
HGNC ID
HGNC:7661

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.P227L .
COLO800 SNV: p.R300Q .
HT115 SNV: p.E496Q .
IGR1 SNV: p.E401K .
IM95 SNV: p.K58N; p.P349H .
Ishikawa (Heraklio) 02 ER SNV: p.H69R .
KMCH1 SNV: p.Y125Ter .
NCIH2170 SNV: p.R77Q .
ONS76 SNV: p.K382T .
SKN Deletion: p.W425VfsTer2 .
SNGM SNV: p.A202V .
SNU1 SNV: p.Q221R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C291(1.56)  LDD3334  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 697 C291(1.46)  LDD2245  [1]
 LDCM0023  KB03 769-P C291(2.58)  LDD2663  [1]
 LDCM0024  KB05 MOLM-16 C291(1.56)  LDD3334  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840