Details of the Target

General Information of Target

Target ID LDTP03010
Target Name Alpha-1-acid glycoprotein 2 (ORM2)
Gene Name ORM2
Gene ID 5005
Synonyms
AGP2; Alpha-1-acid glycoprotein 2; AGP 2; Orosomucoid-2; OMD 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALSWVLTVLSLLPLLEAQIPLCANLVPVPITNATLDRITGKWFYIASAFRNEEYNKSVQ
EIQATFFYFTPNKTEDTIFLREYQTRQNQCFYNSSYLNVQRENGTVSRYEGGREHVAHLL
FLRDTKTLMFGSYLDDEKNWGLSFYADKPETTKEQLGEFYEALDCLCIPRSDVMYTDWKK
DKCEPLEKQHEKERKQEEGES
Target Bioclass
Other
Family
Calycin superfamily, Lipocalin family
Subcellular location
Secreted
Function
Functions as a transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Uniprot ID
P19652
Ensemble ID
ENST00000431067.4
HGNC ID
HGNC:8499
ChEMBL ID
CHEMBL5958

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 50 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Abemaciclib Small molecular drug DB12001
Acalabrutinib Small molecular drug DB11703
Argatroban Small molecular drug DB00278
Asenapine Small molecular drug DB06216
Atazanavir Small molecular drug DB01072
Atomoxetine Small molecular drug DB00289
Benzocaine Small molecular drug DB01086
Carbinoxamine Small molecular drug DB00748
Chloroquine Small molecular drug DB00608
Chlorpromazine Small molecular drug DB00477
Cocaine Small molecular drug DB00907
Crizotinib Small molecular drug DB08865
Disopyramide Small molecular drug DB00280
Dolutegravir Small molecular drug DB08930
Duloxetine Small molecular drug DB00476
Favipiravir Small molecular drug DB12466
Fentanyl Small molecular drug DB00813
Fexofenadine Small molecular drug DB00950
Flecainide Small molecular drug DB01195
Glycopyrronium Small molecular drug DB00986
Hydroxychloroquine Small molecular drug DB01611
Ibrutinib Small molecular drug DB09053
Imipramine Small molecular drug DB00458
Indapamide Small molecular drug DB00808
Ipratropium Small molecular drug DB00332
Irbesartan Small molecular drug DB01029
Istradefylline Small molecular drug DB11757
Labetalol Small molecular drug DB00598
Lidocaine Small molecular drug DB00281
Macitentan Small molecular drug DB08932
Nadolol Small molecular drug DB01203
Neratinib Small molecular drug DB11828
Nifedipine Small molecular drug DB01115
Oxycodone Small molecular drug DB00497
Pindolol Small molecular drug DB00960
Remoxipride Small molecular drug DB00409
Rifampicin Small molecular drug DB01045
Salmeterol Small molecular drug DB00938
Selumetinib Small molecular drug DB11689
Solifenacin Small molecular drug DB01591
Spironolactone Small molecular drug DB00421
Terbinafine Small molecular drug DB00857
Terfenadine Small molecular drug DB00342
Thalidomide Small molecular drug DB01041
Ripretinib . DB14840
Vinflunine . DB11641
Zinc . DB01593
Zinc Acetate . DB14487
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Imidafenacin . DB09262

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.