Details of the Target

General Information of Target

Target ID LDTP03006
Target Name Wilms tumor protein (WT1)
Gene Name WT1
Gene ID 7490
Synonyms
Wilms tumor protein; WT33
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSDVRDLNALLPAVPSLGGGGGCALPVSGAAQWAPVLDFAPPGASAYGSLGGPAPPPAP
PPPPPPPPHSFIKQEPSWGGAEPHEEQCLSAFTVHFSGQFTGTAGACRYGPFGPPPPSQA
SSGQARMFPNAPYLPSCLESQPAIRNQGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHED
PMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQ
MNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESDNHTTPILCGAQYRIHTHGVFRGIQDV
RRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDC
ERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGKTSEKPFSCRWPS
CQKKFARSDELVRHHNMHQRNMTKLQLAL
Target Type
Clinical trial
Target Bioclass
Transcription factor
Family
EGR C2H2-type zinc-finger protein family
Subcellular location
Nucleus; Nucleus speckle; Nucleus, nucleoplasm
Function
Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.
TTD ID
T29960
Uniprot ID
P19544
DrugMap ID
TTZ8UT4
Ensemble ID
ENST00000379079.8
HGNC ID
HGNC:12796
ChEMBL ID
CHEMBL4662942

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C210(3.94)  LDD3392  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Heraklio 02 ER- C210(3.24)  LDD2401  [1]
 LDCM0023  KB03 Heraklio 02 ER- C210(4.31)  LDD2818  [1]
 LDCM0024  KB05 PANC-1 C210(3.94)  LDD3392  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
TGF-beta receptor type-2 (TGFBR2) TKL Ser/Thr protein kinase family P37173
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTPase HRas (HRAS) Ras family P01112
Methylcytosine dioxygenase TET2 (TET2) TET family Q6N021
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Importin-8 (IPO8) Importin beta family O15397
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Class E basic helix-loop-helix protein 40 (BHLHE40) . O14503
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet endothelial cell adhesion molecule (PECAM1) . P16284
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Pre-mRNA-splicing regulator WTAP (WTAP) Fl(2)d family Q15007
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 10-6 (KRTAP10-6) KRTAP type 10 family P60371
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Oxysterol-binding protein-related protein 3 (OSBPL3) OSBP family Q9H4L5
DnaJ homolog subfamily B member 1 (DNAJB1) . P25685
PRKCA-binding protein (PICK1) . Q9NRD5
Sequestosome-1 (SQSTM1) . Q13501

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Combined Pr1/Wt1 Vaccine Vaccine D0O8AY
Fpi-01 Vaccine D0RG8Z
Wt1 Peptide Vaccine Vaccine D00QXB
Wt1-targeted Autologous Dendritic Cell Vaccine Vaccine D02MLO
Wt-4869 . D01MYJ
Phase 1
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gsk-2130579a Vaccine D02JEW
Inno-305 . D0P2ZY

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019