Details of the Target
General Information of Target
| Target ID | LDTP02966 | |||||
|---|---|---|---|---|---|---|
| Target Name | Syndecan-1 (SDC1) | |||||
| Gene Name | SDC1 | |||||
| Gene ID | 6382 | |||||
| Synonyms |
SDC; Syndecan-1; SYND1; CD antigen CD138 |
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| 3D Structure | ||||||
| Sequence |
MRRAALWLWLCALALSLQPALPQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQ
TPSTWKDTQLLTAIPTSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQE ATPRPRETTQLPTTHLASTTTATTAQEPATSHPHRDMQPGHHETSTPAGPSQADLHTPHT EDGGPSATERAAEDGASSQLPAAEGSGEQDFTFETSGENTAVVAVEPDRRNQSPVDQGAT GASQGLLDRKEVLGGVIAGGLVGLIFAVCLVGFMLYRMKKKDEGSYSLEEPKQANGGAYQ KPTKQEEFYA |
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| Target Type |
Clinical trial
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| Target Bioclass |
Transporter and channel
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| Family |
Syndecan proteoglycan family
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| Subcellular location |
Membrane
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| Function |
Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway.
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| TTD ID | ||||||
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Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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Probe 1 Probe Info |
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Y286(9.13) | LDD3495 | [1] | |