Details of the Target

General Information of Target

Target ID LDTP02905
Target Name T-cell acute lymphocytic leukemia protein 1 (TAL1)
Gene Name TAL1
Gene ID 6886
Synonyms
BHLHA17; SCL; TCL5; T-cell acute lymphocytic leukemia protein 1; TAL-1; Class A basic helix-loop-helix protein 17; bHLHa17; Stem cell protein; T-cell leukemia/lymphoma protein 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTERPPSEAARSDPQLEGRDAAEASMAPPHLVLLNGVAKETSRAAAAEPPVIELGARGGP
GGGPAGGGGAARDLKGRDAATAEARHRVPTTELCRPPGPAPAPAPASVTAELPGDGRMVQ
LSPPALAAPAAPGRALLYSLSQPLASLGSGFFGEPDAFPMFTTNNRVKRRPSPYEMEITD
GPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFLA
KLLNDQEEEGTQRAKTGKDPVVGAGGGGGGGGGGAPPDDLLQDVLSPNSSCGSSLDGAAS
PDSYTEEPAPKHTARSLHPAMLPAADGAGPR
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.
Uniprot ID
P17542
Ensemble ID
ENST00000294339.3
HGNC ID
HGNC:11556

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Insertion: p.N204KfsTer24 .
8305C SNV: p.P124S .
CCK81 Deletion: p.G62AfsTer13 .
HCT116 Deletion: p.G62AfsTer13 .
MFE319 SNV: p.T313A .
SKMEL28 SNV: p.G270V .
SKNSH SNV: p.P50Q .
TOV21G SNV: p.A275S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C291(6.34); C94(10.00)  LDD2157  [1]
DBIA
 Probe Info  		C94(1.08)  LDD2351  [2]
1d-yne
 Probe Info  		N.A.  LDD0357  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HEL C94(1.08)  LDD2351  [2]
 LDCM0023  KB03 HEL C94(1.06)  LDD2768  [2]
 LDCM0024  KB05 EoL-1 C94(1.43)  LDD3158  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein C-ets-1 (ETS1) ETS family P14921
Runt-related transcription factor 1 (RUNX1) . Q01196
Transcription factor 12 (TCF12) . Q99081
Transcription factor 4 (TCF4) . P15884
Transcription factor E2-alpha (TCF3) . P15923
Transcriptional activator Myb (MYB) . P10242

References

1 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.