Details of the Target

General Information of Target

Target ID LDTP02875
Target Name Zinc finger protein 18 (ZNF18)
Gene Name ZNF18
Gene ID 7566
Synonyms
HDSG1; KOX11; ZKSCAN6; ZNF535; Zinc finger protein 18; Heart development-specific gene 1 protein; Zinc finger protein 535; Zinc finger protein KOX11; Zinc finger protein with KRAB and SCAN domains 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPVDLGQALGLLPSLAKAEDSQFSESDAALQEELSSPETARQLFRQFRYQVMSGPHETLK
QLRKLCFQWLQPEVHTKEQILEILMLEQFLTILPGEIQMWVRKQCPGSGEEAVTLVESLK
GDPQRLWQWISIQVLGQDILSEKMESPSCQVGEVEPHLEVVPQELGLENSSSGPGELLSH
IVKEESDTEAELALAASQPARLEERLIRDQDLGASLLPAAPQEQWRQLDSTQKEQYWDLM
LETYGKMVSGAGISHPKSDLTNSIEFGEELAGIYLHVNEKIPRPTCIGDRQENDKENLNL
ENHRDQELLHASCQASGEVPSQASLRGFFTEDEPGCFGEGENLPEALQNIQDEGTGEQLS
PQERISEKQLGQHLPNPHSGEMSTMWLEEKRETSQKGQPRAPMAQKLPTCRECGKTFYRN
SQLIFHQRTHTGETYFQCTICKKAFLRSSDFVKHQRTHTGEKPCKCDYCGKGFSDFSGLR
HHEKIHTGEKPYKCPICEKSFIQRSNFNRHQRVHTGEKPYKCSHCGKSFSWSSSLDKHQR
SHLGKKPFQ
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
P17022
Ensemble ID
ENST00000322748.7
HGNC ID
HGNC:12969

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAKI1 SNV: p.G107A .
CORL88 SNV: p.R205M .
HCT15 SNV: p.L81I; p.Y468Ter .
HSC3 SNV: p.E242K .
SF295 SNV: p.A315D .
SHP77 SNV: p.I83T .
SNU1 SNV: p.E19G .
SNU245 SNV: p.T188A .
UMUC3 SNV: p.Q198K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-465
 Probe Info  		K490(0.00); K493(0.00); Y492(0.00)  LDD2240  [1]

References

1 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010