Details of the Target
General Information of Target
| Target ID | LDTP02857 | |||||
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| Target Name | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (GNB3) |
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| Gene Name | GNB3 | |||||
| Gene ID | 2784 | |||||
| Synonyms |
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; Transducin beta chain 3 |
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| 3D Structure | ||||||
| Sequence |
MGEMEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYA
MHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNM CSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVF VGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEA ICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSM KSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN |
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| Target Bioclass |
Other
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| Family |
WD repeat G protein beta family
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| Function |
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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STPyne Probe Info |
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K23(9.10) | LDD0277 | [1] | |
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DBIA Probe Info |
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C25(0.82) | LDD3344 | [2] | |
PAL-AfBPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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STS-2 Probe Info |
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N.A. | LDD0139 | [3] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
References