Details of the Target

General Information of Target

Target ID LDTP02803
Target Name T-cell surface glycoprotein CD1e, membrane-associated (CD1E)
Gene Name CD1E
Gene ID 913
Synonyms
T-cell surface glycoprotein CD1e, membrane-associated; hCD1e; R2G1; CD antigen CD1e) [Cleaved into: T-cell surface glycoprotein CD1e, soluble; sCD1e)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLLFLLFEGLCCPGENTAAPQALQSYHLAAEEQLSFRMLQTSSFANHSWAHSEGSGWLG
DLQTHGWDTVLGTIRFLKPWSHGNFSKQELKNLQSLFQLYFHSFIQIVQASAGQFQLEYP
FEIQILAGCRMNAPQIFLNMAYQGSDFLSFQGISWEPSPGAGIRAQNICKVLNRYLDIKE
ILQSLLGHTCPRFLAGLMEAGESELKRKVKPEAWLSCGPSPGPGRLQLVCHVSGFYPKPV
WVMWMRGEQEQRGTQRGDVLPNADETWYLRATLDVAAGEAAGLSCRVKHSSLGGHDLIIH
WGGYSIFLILICLTVIVTLVILVVVDSRLKKQSSNKNILSPHTPSPVFLMGANTQDTKNS
RHQFCLAQVSWIKNRVLKKWKTRLNQLW
Target Bioclass
Immunoglobulin
Subcellular location
Lysosome lumen; Golgi apparatus membrane
Function
T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.
Uniprot ID
P15812
Ensemble ID
ENST00000368154.5
HGNC ID
HGNC:1638

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL72 SNV: p.H82N .
EFO27 SNV: p.C230R .
HCC15 Substitution: p.Q106G .
HT115 SNV: p.V317F .
LOXIMVI SNV: p.V369I .
MCC26 SNV: p.K179T; p.E265D .
MEWO SNV: p.P120L; p.M198I .
NCIH661 SNV: p.L7I; p.G113C .
RL952 SNV: p.V232I .
YSCCC SNV: p.S145L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C28(1.27)  LDD3397  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		C190(0.00); C217(0.00); C365(0.00)  LDD0038  [2]
IA-alkyne
 Probe Info  		C190(0.00); C217(0.00); C365(0.00)  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		C285(0.00); C190(0.00); C217(0.00); C365(0.00)  LDD0037  [2]
Compound 10
 Probe Info  		C190(0.00); C365(0.00)  LDD2216  [3]
Compound 11
 Probe Info  		C190(0.00); C365(0.00)  LDD2213  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Jurkat C28(1.84)  LDD2409  [1]
 LDCM0023  KB03 Jurkat C28(2.62)  LDD2826  [1]
 LDCM0024  KB05 PF-382 C28(1.27)  LDD3397  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279