Details of the Target

General Information of Target

Target ID LDTP02791
Target Name Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (CSF2RA)
Gene Name CSF2RA
Gene ID 1438
Synonyms
CSF2R; CSF2RY; Granulocyte-macrophage colony-stimulating factor receptor subunit alpha; GM-CSF-R-alpha; GMCSFR-alpha; GMR-alpha; CDw116; CD antigen CD116
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLLVTSLLLCELPHPAFLLIPEKSDLRTVAPASSLNVRFDSRTMNLSWDCQENTTFSKC
FLTDKKNRVVEPRLSNNECSCTFREICLHEGVTFEVHVNTSQRGFQQKLLYPNSGREGTA
AQNFSCFIYNADLMNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHL
DNLSGLTSRNYFLVNGTSREIGIQFFDSLLDTKKIERFNPPSNVTVRCNTTHCLVRWKQP
RTYQKLSYLDFQYQLDVHRKNTQPGTENLLINVSGDLENRYNFPSSEPRAKHSVKIRAAD
VRILNWSSWSEAIEFGSDDGNLGSVYIYVLLIVGTLVCGIVLGFLFKRFLRIQRLFPPVP
QIKDKLNDNHEVEDEIIWEEFTPEEGKGYREEVLTVKEIT
Target Type
Successful
Target Bioclass
Cytokine and receptor
Family
Type I cytokine receptor family, Type 5 subfamily
Subcellular location
Secreted; Cell membrane
Function Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
TTD ID
T73097
Uniprot ID
P15509
DrugMap ID
TT6MP2Z
Ensemble ID
ENST00000355432.8
HGNC ID
HGNC:2435
ChEMBL ID
CHEMBL2364169

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.E380K .
G361 SNV: p.R241K .
HT115 SNV: p.I271S .
SUPT1 SNV: p.R302C .
TOV21G SNV: p.S25L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K108(0.66)  LDD3494  [1]

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888