Details of the Target

General Information of Target

Target ID LDTP02787
Target Name Fos-related antigen 2 (FOSL2)
Gene Name FOSL2
Gene ID 2355
Synonyms
FRA2; Fos-related antigen 2; FRA-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYQDYPGNFDTSSRGSSGSPAHAESYSSGGGGQQKFRVDMPGSGSAFIPTINAITTSQDL
QWMVQPTVITSMSNPYPRSHPYSPLPGLASVPGHMALPRPGVIKTIGTTVGRRRRDEQLS
PEEEEKRRIRRERNKLAAAKCRNRRRELTEKLQAETEELEEEKSGLQKEIAELQKEKEKL
EFMLVAHGPVCKISPEERRSPPAPGLQPMRSGGGSVGAVVVKQEPLEEDSPSSSSAGLDK
AQRSVIKPISIAGGFYGEEPLHTPIVVTSTPAVTPGTSNLVFTYPSVLEQESPASPSESC
SKAHRRSSSSGDQSSDSLNSPTLLAL
Target Type
Literature-reported
Target Bioclass
Transcription factor
Family
BZIP family, Fos subfamily
Subcellular location
Nucleus
Function Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.
TTD ID
T32600
Uniprot ID
P15408
DrugMap ID
TT689IR
Ensemble ID
ENST00000264716.9
HGNC ID
HGNC:3798

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.V102M; p.L226M .
HEC1B SNV: p.V102M; p.L226M .
L428 SNV: p.P189A .
MOLT4 SNV: p.R128H .
P31FUJ SNV: p.S71P .
T24 Deletion: p.G205AfsTer53 .
T98G SNV: p.R128C .
TOV21G SNV: p.S232Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C191(1.57)  LDD3342  [1]
m-APA
 Probe Info  		N.A.  LDD2231  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 42-MG-BA C191(2.00)  LDD2244  [1]
 LDCM0023  KB03 42-MG-BA C191(2.32)  LDD2661  [1]
 LDCM0024  KB05 NCI-H1155 C191(1.57)  LDD3342  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerase II subunit RPB7 (POLR2G) Eukaryotic RPB7/RPC8 RNA polymerase subunit family P62487
Nucleoside diphosphate kinase homolog 7 (NME7) NDK family Q9Y5B8
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTPase HRas (HRAS) Ras family P01112
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgi-associated PDZ and coiled-coil motif-containing protein (GOPC) . Q9HD26
Transcription factor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-7 (ATF7) BZIP family P17544
DNA damage-inducible transcript 3 protein (DDIT3) BZIP family P35638
Nuclear factor erythroid 2-related factor 2 (NFE2L2) BZIP family Q16236
Transcription regulator protein BACH2 (BACH2) BZIP family Q9BYV9
Transcription factor Jun (JUN) BZIP family P05412
Transcription factor JunB (JUNB) BZIP family P17275
Transcription factor JunD (JUND) BZIP family P17535
LIM/homeobox protein Lhx8 (LHX8) . Q68G74
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-2 (ATF2) BZIP family P15336
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ligand-dependent nuclear receptor-interacting factor 1 (LRIF1) LRIF1 family Q5T3J3
Gelsolin (GSN) Villin/gelsolin family P06396
Cytohesin-1 (CYTH1) . Q15438
Four and a half LIM domains protein 3 (FHL3) . Q13643
Leucine zipper protein 4 (LUZP4) . Q9P127
TNF receptor-associated factor 1 (TRAF1) . Q13077
Ubiquilin-1 (UBQLN1) . Q9UMX0

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264