General Information of Target

Target ID LDTP02763
Target Name Fatty acid-binding protein, adipocyte (FABP4)
Gene Name FABP4
Gene ID 2167
Synonyms
Fatty acid-binding protein, adipocyte; Adipocyte lipid-binding protein; ALBP; Adipocyte-type fatty acid-binding protein; A-FABP; AFABP; Fatty acid-binding protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDVITIKSESTFKN
TEISFILGQEFDEVTADDRKVKSTITLDGGVLVHVQKWDGKSTTIKRKREDDKLVVECVM
KGVTSTRVYERA
Target Type
Patented-recorded
Target Bioclass
Other
Family
Calycin superfamily, Fatty-acid binding protein (FABP) family
Subcellular location
Cytoplasm
Function Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.
TTD ID
T07217
Uniprot ID
P15090
DrugMap ID
TTHWMFZ
Ensemble ID
ENST00000256104.5
HGNC ID
HGNC:3559
ChEMBL ID
CHEMBL2083

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C118(8.62)  LDD3345  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A204 C118(1.21)  LDD2252  [1]
 LDCM0023  KB03 A-549 C118(1.93)  LDD2677  [1]
 LDCM0024  KB05 NCI-H1650 C118(8.62)  LDD3345  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840