Details of the Target

General Information of Target

Target ID LDTP02754
Target Name D-amino-acid oxidase (DAO)
Gene Name DAO
Gene ID 1610
Synonyms
DAMOX; D-amino-acid oxidase; DAAO; DAMOX; DAO; EC 1.4.3.3
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPN
NPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPR
ELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVN
CTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGG
IFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGP
SNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
DAMOX/DASOX family
Subcellular location
Peroxisome
Function
Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.
TTD ID
T33124
Uniprot ID
P14920
DrugMap ID
TT7Y3EJ
Ensemble ID
ENST00000228476.8
HGNC ID
HGNC:2671
ChEMBL ID
CHEMBL5485

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ATP probe
 Probe Info  		N.A.  LDD0035  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Benzoic Acid Small molecular drug DB03793
Flavin Adenine Dinucleotide Small molecular drug DB03147
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Tak-831 . D03RXS
Investigative
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
D-tryptophan Small molecular drug DB03225
(2e)-3-(34-dihydroxyphenyl)-2-iminopropanoic Acid . DB07979
34-dihydro-2h-pyrrolium-5-carboxylate . DB02838
Anthranilic Acid . DB04166
Flavin-adenine Dinucleotide-n5-isobutyl Ketone . DB03531
Imino-tryptophan . DB02988
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sep-227900 . D0XW4W

References

1 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096