Details of the Target
General Information of Target
| Target ID | LDTP02742 | |||||
|---|---|---|---|---|---|---|
| Target Name | Tyrosinase (TYR) | |||||
| Gene Name | TYR | |||||
| Gene ID | 7299 | |||||
| Synonyms |
Tyrosinase; EC 1.14.18.1; LB24-AB; Monophenol monooxygenase; SK29-AB; Tumor rejection antigen AB |
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| 3D Structure | ||||||
| Sequence |
MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILL
SNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVR RNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMH YYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRD AEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRN PGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQS SMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGH NRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLG AAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL |
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| Target Type |
Successful
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| Target Bioclass |
Enzyme
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| Family |
Tyrosinase family
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| Subcellular location |
Melanosome membrane
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| Function |
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.
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| TTD ID | ||||||
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| ChEMBL ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| COLO792 | SNV: p.S331F | DBIA Probe Info | |||
| HCT15 | SNV: p.S79L | . | |||
| HGC27 | SNV: p.R196G | . | |||
| IGR1 | Insertion: p.S26dup | DBIA Probe Info | |||
| MEWO | SNV: p.S441L | DBIA Probe Info | |||
| MFE319 | SNV: p.Y156C | . | |||
| MOLT4 | SNV: p.D437G; p.S441L | . | |||
| NCIH1703 | SNV: p.L2F | . | |||
| NCIH82 | SNV: p.P457S | . | |||
| TGBC1TKB | SNV: p.P81H | . | |||
| UACC62 | SNV: p.P70S | DBIA Probe Info | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C55(2.13); C46(3.12) | LDD3332 | [1] | |
Competitor(s) Related to This Target