Details of the Target

General Information of Target

Target ID LDTP02737
Target Name Homeobox protein Hox-B3 (HOXB3)
Gene Name HOXB3
Gene ID 3213
Synonyms
HOX2G; Homeobox protein Hox-B3; Homeobox protein Hox-2.7; Homeobox protein Hox-2G
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQKATYYDNAAAALFGGYSSYPGSNGFGFDVPPQPPFQAATHLEGDYQRSACSLQSLGNA
APHAKSKELNGSCMRPGLAPEPLSAPPGSPPPSAAPTSATSNSSNGGGPSKSGPPKCGPG
TNSTLTKQIFPWMKESRQTSKLKNNSPGTAEGCGGGGGGGGGGGSGGSGGGGGGGGGGDK
SPPGSAASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRR
MKYKKDQKAKGLASSSGGPSPAGSPPQPMQSTAGFMNALHSMTPSYESPSPPAFGKAHQN
AYALPSNYQPPLKGCGAPQKYPPTPAPEYEPHVLQANGGAYGTPTMQGSPVYVGGGGYAD
PLPPPAGPSLYGLNHLSHHPSGNLDYNGAPPMAPSQHHGPCEPHPTYTDLSSHHAPPPQG
RIQEAPKLTHL
Target Bioclass
Transcription factor
Family
Antp homeobox family
Subcellular location
Nucleus
Function Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Uniprot ID
P14651
Ensemble ID
ENST00000311626.8
HGNC ID
HGNC:5114

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.P368L .
CAL51 SNV: p.S168G .
HEC1B SNV: p.Y47D .
Ishikawa (Heraklio) 02 ER SNV: p.N374D .
KMCH1 SNV: p.P361S .
MDST8 Deletion: p.G176_G178del .
MFE319 Insertion: p.S260IfsTer37 .
NCIH2052 SNV: p.P265H; p.P268H .
REH Deletion: p.G258AfsTer19; p.G356AfsTer73 .
SNGM SNV: p.I232L .
SUPT1 Deletion: p.P183RfsTer37
SNV: p.A415V		 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [1]

References

1 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004