Details of the Target

General Information of Target

Target ID LDTP02727
Target Name D(2) dopamine receptor (DRD2)
Gene Name DRD2
Gene ID 1813
Synonyms
D(2) dopamine receptor; Dopamine D2 receptor
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
VNPIIYTTFNIEFRKAFLKILHC
Target Type
Successful
Target Bioclass
GPCR
Family
G-protein coupled receptor 1 family
Subcellular location
Cell membrane
Function
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5.
TTD ID
T67162
Uniprot ID
P14416
DrugMap ID
TTEX248
Ensemble ID
ENST00000346454.7
HGNC ID
HGNC:3023
ChEMBL ID
CHEMBL217

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.V59M .
HCC15 SNV: p.P299A .
HDQP1 SNV: p.I383M .
HEC1B SNV: p.S288N .
HG3 SNV: p.V83I .
HT115 SNV: p.Y213D; p.E278K .
ICC9 SNV: p.R222Q .
IGR37 SNV: p.D2N .
IGR39 SNV: p.D2N .
KMCH1 SNV: p.Y37C .
KP4 SNV: p.K439N .
KURAMOCHI SNV: p.L174F .
MCC26 Substitution: p.P308L .
REH SNV: p.G380S .
SAOS2 SNV: p.T412S .
SKNMC SNV: p.R15K .
SW1783 SNV: p.V196I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C253(20.00)  LDD2227  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C253(20.00)  LDD2227  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264