Details of the Target

General Information of Target

Target ID LDTP02723
Target Name Carboxypeptidase M (CPM)
Gene Name CPM
Gene ID 1368
Synonyms
Carboxypeptidase M; CPM; EC 3.4.17.12
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVL
VVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKDPEITNLINSTRIH
IMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYNNVSRQPETVAVMKWLKT
ETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGD
ECKNKMNFPNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNN
KASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSY
IINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQLDSIPVSNPSCPMIPLYRNLP
DHSAATKPSLFLFLVSLLHIFFK
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Peptidase M14 family
Subcellular location
Cell membrane
Function
Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.
TTD ID
T65483
Uniprot ID
P14384
DrugMap ID
TTVOH2M
Ensemble ID
ENST00000338356.7
HGNC ID
HGNC:2311
ChEMBL ID
CHEMBL3038

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K135(0.99); K338(4.51)  LDD3494  [1]
DBIA
 Probe Info  		C341(1.30)  LDD3312  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
Acrolein
 Probe Info  		N.A.  LDD0217  [4]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [4]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0107  IAA HeLa N.A.  LDD0221  [4]
 LDCM0022  KB02 697 C341(1.10)  LDD2245  [2]
 LDCM0023  KB03 8305C C341(1.76)  LDD2665  [2]
 LDCM0024  KB05 HMCB C341(1.30)  LDD3312  [2]
 LDCM0109  NEM HeLa N.A.  LDD0230  [4]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid14640538c3 Small molecular drug D0XA0N

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.