Details of the Target
General Information of Target
| Target ID | LDTP02709 | |||||
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| Target Name | Cathepsin E (CTSE) |
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| Gene Name | CTSE | |||||
| Gene ID | 1510 | |||||
| Synonyms |
Cathepsin E; EC 3.4.23.34) [Cleaved into: Cathepsin E form I; Cathepsin E form II] |
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| 3D Structure | ||||||
| Sequence |
MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESC
SMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRF QPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAE FDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSH FSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNA IGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDI HPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPAVP |
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| Target Type |
Literature-reported
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| Target Bioclass |
Enzyme
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| Family |
Peptidase A1 family
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| Subcellular location |
Endosome
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| Function |
May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.
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| TTD ID | ||||||
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Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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STPyne Probe Info |
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K33(2.94) | LDD0277 | [1] | |