Details of the Target
General Information of Target
| Target ID | LDTP02670 | |||||
|---|---|---|---|---|---|---|
| Target Name | Retinoic acid receptor gamma (RARG) | |||||
| Gene Name | RARG | |||||
| Gene ID | 5916 | |||||
| Synonyms |
NR1B3; Retinoic acid receptor gamma; RAR-gamma; Nuclear receptor subfamily 1 group B member 3 |
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| 3D Structure | ||||||
| Sequence |
MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMAS
LSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQK NMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSY ELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIK IVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMH NAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEA LRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPE MFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA |
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| Target Type |
Successful
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| Target Bioclass |
Transcription factor
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| Family |
Nuclear hormone receptor family, NR1 subfamily
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| Subcellular location |
Nucleus
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| Function |
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function.
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| TTD ID | ||||||
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Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| HKGZCC | SNV: p.D385N | DBIA Probe Info | |||
| JURKAT | SNV: p.R115H | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C54(1.38) | LDD3312 | [1] | |
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NAIA_5 Probe Info |
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C205(0.00); C203(0.00) | LDD2224 | [2] | |
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IPM Probe Info |
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N.A. | LDD2156 | [3] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Transporter and channel
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Bardet-Biedl syndrome 4 protein (BBS4) | BBS4 family | Q96RK4 | |||
Transcription factor
Other
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| cAMP-dependent protein kinase type I-beta regulatory subunit (PRKAR1B) | CAMP-dependent kinase regulatory chain family | P31321 | |||
The Drug(s) Related To This Target
Approved
Phase 3
| Drug Name | Drug Type | External ID | |||
|---|---|---|---|---|---|
| Palovarotene | Small molecular drug | D0H8OH | |||
Investigative
Patented
Discontinued
| Drug Name | Drug Type | External ID | |||
|---|---|---|---|---|---|
| Etretinate | Small molecular drug | DB00926 | |||
References