Details of the Target
General Information of Target
| Target ID | LDTP02667 | |||||
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| Target Name | Intercellular adhesion molecule 2 (ICAM2) |
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| Gene Name | ICAM2 | |||||
| Gene ID | 3384 | |||||
| Synonyms |
Intercellular adhesion molecule 2; ICAM-2; CD antigen CD102 |
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| 3D Structure | ||||||
| Sequence |
MSSFGYRTLTVALFTLICCPGSDEKVFEVHVRPKKLAVEPKGSLEVNCSTTCNQPEVGGL
ETSLDKILLDEQAQWKHYLVSNISHDTVLQCHFTCSGKQESMNSNVSVYQPPRQVILTLQ PTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTAD REDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVVSVLLSLFVT SVLLCFIFGQHLRQQRMGTYGVRAAWRRLPQAFRP |
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| Target Bioclass |
Immunoglobulin
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| Family |
Immunoglobulin superfamily, ICAM family
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| Subcellular location |
Membrane
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| Function |
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C134(1.56) | LDD3380 | [1] | |
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4-Iodoacetamidophenylacetylene Probe Info |
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N.A. | LDD0038 | [2] | |
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IA-alkyne Probe Info |
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N.A. | LDD0036 | [2] | |
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Lodoacetamide azide Probe Info |
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N.A. | LDD0037 | [2] | |
Competitor(s) Related to This Target
References