Details of the Target

General Information of Target

Target ID LDTP02648
Target Name Platelet glycoprotein Ib beta chain (GP1BB)
Gene Name GP1BB
Gene ID 2812
Synonyms
Platelet glycoprotein Ib beta chain; GP-Ib beta; GPIb-beta; GPIbB; Antigen CD42b-beta; CD antigen CD42c
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSGPRGALSLLLLLLAPPSRPAAGCPAPCSCAGTLVDCGRRGLTWASLPTAFPVDTTEL
VLTGNNLTALPPGLLDALPALRTAHLGANPWRCDCRLVPLRAWLAGRPERAPYRDLRCVA
PPALRGRLLPYLAEDELRAACAPGPLCWGALAAQLALLGLGLLHALLLVLLLCRLRRLRA
RARARAAARLSLTDPLVAERAGTDES
Target Bioclass
Other
Subcellular location
Membrane
Function Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.
Uniprot ID
P13224
Ensemble ID
ENST00000366425.4
HGNC ID
HGNC:4440

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.P71L .
HEPG2 SNV: p.L158V .
Ishikawa (Heraklio) 02 ER SNV: p.L12P .
NCIH2172 SNV: p.P22S .
U118MG SNV: p.A139S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C323(3.02)  LDD3335  [1]
N1
 Probe Info  		N.A.  LDD0245  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 CMK C323(2.50)  LDD2302  [1]
 LDCM0023  KB03 CMK C323(3.90)  LDD2719  [1]
 LDCM0024  KB05 MONO-MAC-6 C323(3.02)  LDD3335  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet glycoprotein Ib alpha chain (GP1BA) . P07359
Platelet glycoprotein Ib beta chain (GP1BB) . P13224

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.