General Information of Target

Target ID LDTP02633
Target Name Myosin light chain 4 (MYL4)
Gene Name MYL4
Gene ID 4635
Synonyms
MLC1; Myosin light chain 4; Myosin light chain 1, embryonic muscle/atrial isoform; Myosin light chain alkali GT-1 isoform
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPKKPEPKKEAAKPAPAPAPAPAPAPAPAPEAPKEPAFDPKSVKIDFTADQIEEFKEAF
SLFDRTPTGEMKITYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNVKMLDFETFLPIL
QHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKMTEAEVEQLLAGQED
ANGCINYEAFVKHIMSG
Target Bioclass
Other
Function Regulatory light chain of myosin. Does not bind calcium.
Uniprot ID
P12829
Ensemble ID
ENST00000354968.5
HGNC ID
HGNC:7585
ChEMBL ID
CHEMBL3831286

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C78(0.52)  LDD3334  [1]
m-APA
 Probe Info 
N.A.  LDD2234  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 CMK C78(1.18)  LDD2302  [1]
 LDCM0023  KB03 CMK C78(0.93)  LDD2719  [1]
 LDCM0024  KB05 MOLM-16 C78(0.52)  LDD3334  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377