Details of the Target

General Information of Target

Target ID LDTP02628
Target Name Eosinophil cationic protein (RNASE3)
Gene Name RNASE3
Gene ID 6037
Synonyms
ECP; RNS3; Eosinophil cationic protein; ECP; EC 3.1.27.-; Ribonuclease 3; RNase 3
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MVPKLFTSQICLLLLLGLMGVEGSLHARPPQFTRAQWFAIQHISLNPPRCTIAMRAINNY
RWRCKNQNTFLRTTFANVVNVCGNQSIRCPHNRTLNNCHRSRFRVPLLHCDLINPGAQNI
SNCTYADRPGRRFYVVACDNRDPRDSPRYPVVPVHLDTTI
Target Bioclass
Enzyme
Family
Pancreatic ribonuclease family
Subcellular location
Secreted
Function
Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.
Uniprot ID
P12724
Ensemble ID
ENST00000304639.4
HGNC ID
HGNC:10046

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C138(0.27)  LDD2236  [1]

References

1 Global profiling of phosphorylation-dependent changes in cysteine reactivity. Nat Methods. 2022 Mar;19(3):341-352. doi: 10.1038/s41592-022-01398-2. Epub 2022 Feb 28.
Mass spectrometry data entry: PXD026730