Details of the Target

General Information of Target

Target ID LDTP02604
Target Name Collagen alpha-1(XI) chain (COL11A1)
Gene Name COL11A1
Gene ID 1301
Synonyms
COLL6; Collagen alpha-1(XI) chain
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPWSSRWKTKRWLWDFTVTTLALTFLFQAREVRGAAPVDVLKALDFHNSPEGISKTTGF
CTNRKNSKGSDTAYRVSKQAQLSAPTKQLFPGGTFPEDFSILFTVKPKKGIQSFLLSIYN
EHGIQQIGVEVGRSPVFLFEDHTGKPAPEDYPLFRTVNIADGKWHRVAISVEKKTVTMIV
DCKKKTTKPLDRSERAIVDTNGITVFGTRILDEEVFEGDIQQFLITGDPKAAYDYCEHYS
PDCDSSAPKAAQAQEPQIDEYAPEDIIEYDYEYGEAEYKEAESVTEGPTVTEETIAQTEA
NIVDDFQEYNYGTMESYQTEAPRHVSGTNEPNPVEEIFTEEYLTGEDYDSQRKNSEDTLY
ENKEIDGRDSDLLVDGDLGEYDFYEYKEYEDKPTSPPNEEFGPGVPAETDITETSINGHG
AYGEKGQKGEPAVVEPGMLVEGPPGPAGPAGIMGPPGLQGPTGPPGDPGDRGPPGRPGLP
GADGLPGPPGTMLMLPFRYGGDGSKGPTISAQEAQAQAILQQARIALRGPPGPMGLTGRP
GPVGGPGSSGAKGESGDPGPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDR
GFDGLPGLPGDKGHRGERGPQGPPGPPGDDGMRGEDGEIGPRGLPGEAGPRGLLGPRGTP
GAPGQPGMAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKP
GLAGLPGADGPPGHPGKEGQSGEKGALGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEK
GEDGFPGFKGDMGLKGDRGEVGQIGPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVP
GLPGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKP
GPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKT
GPPGPGGVVGPQGPTGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAKGDPGPQGISGKD
GPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQ
GPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSK
GDKGENGPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGARGFPGPPGPIGLQ
GLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGPQGPPGSVGSVGGVGEKGEPGEA
GNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPP
GEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAK
GEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPMGPPGLP
GLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGPLGPP
GPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGPPGSPGPPGEVIQPLPILSSKKTRRHTEG
MQADADDNILDYSDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPDG
EYWIDPNQGCSGDSFKVYCNFTSGGETCIYPDKKSEGVRISSWPKEKPGSWFSEFKRGKL
LSYLDVEGNSINMVQMTFLKLLTASARQNFTYHCHQSAAWYDVSSGSYDKALRFLGSNDE
EMSYDNNPFIKTLYDGCASRKGYEKTVIEINTPKIDQVPIVDVMINDFGDQNQKFGFEVG
PVCFLG
Target Bioclass
Other
Family
Fibrillar collagen family
Subcellular location
Secreted, extracellular space, extracellular matrix
Function May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.
Uniprot ID
P12107
Ensemble ID
ENST00000353414.8
HGNC ID
HGNC:2186
ChEMBL ID
CHEMBL2364188

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A101D SNV: p.E335Ter DBIA    Probe Info 
A431 SNV: p.G715A .
CAL148 SNV: p.G1441V .
CAL27 SNV: p.R1707P .
CAL62 SNV: p.E320G .
CHL1 SNV: p.G1006S DBIA    Probe Info 
DU145 SNV: p.P999H; p.G1528C .
FTC133 SNV: p.K1485E .
HCC15 SNV: p.G826C .
HCT15 SNV: p.G478S; p.V764L; p.G850C; p.G1272C .
HEC1 SNV: p.Q561H .
HEC1B SNV: p.Q561H .
HLF SNV: p.E385D .
HT115 SNV: p.F306S; p.L1154F .
HUH1 Deletion: p.I1660NfsTer18
SNV: p.V1723M		 DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER Deletion: p.P546LfsTer87
Insertion: p.G110RfsTer11		 .
JHH7 SNV: p.G1581S .
K562 SNV: p.M178I .
LS180 Insertion: p.G676RfsTer38
SNV: p.I509V;p.Q1176H		 .
MCC13 SNV: p.G577E .
MELHO SNV: p.G93E .
MEWO SNV: p.S5F; p.S113F; p.G814E; p.G1030E; p.P1151S; p.E1208K; p.G1360E; p.P1533S .
MIAPACA2 SNV: p.K959R .
NCIH196 SNV: p.E1185V .
NCIH2172 SNV: p.R600L .
NCIH2286 SNV: p.G934C .
NCIH2291 SNV: p.S1727I .
NCIH661 SNV: p.G1204A .
ONS76 SNV: p.P1100S; p.G1447S .
PF382 SNV: p.F1749S .
RKO SNV: p.G637V .
SKMEL28 SNV: p.S1661L .
SKMEL30 SNV: p.S246L .
SKOV3 SNV: p.G1471S .
SNGM Insertion: p.S1655IfsTer2
SNV: .		 .
SNU1 SNV: p.V927I .
SNU245 SNV: p.Q1793E .
SW620 SNV: p.E617Ter .
WM115 SNV: p.G748D; p.G1018E .
WM2664 Insertion: p.D181Ter;p.A1290CfsTer12
SNV: p.G748D;p.G1018E		 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K1654(10.00)  LDD0277  [1]
DBIA
 Probe Info  		C1815(1.88); C1769(2.55)  LDD3410  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A101D C1815(2.31); C1769(2.17)  LDD2250  [2]
 LDCM0023  KB03 A101D C1815(3.91); C1769(2.34)  LDD2667  [2]
 LDCM0024  KB05 RPMI-7951 C1815(1.88); C1769(2.55)  LDD3410  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840