Details of the Target
General Information of Target
Target ID | LDTP02601 | |||||
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Target Name | Cytochrome c oxidase subunit 6A1, mitochondrial (COX6A1) | |||||
Gene Name | COX6A1 | |||||
Gene ID | 1337 | |||||
Synonyms |
COX6AL; Cytochrome c oxidase subunit 6A1, mitochondrial; Cytochrome c oxidase polypeptide VIa-liver; Cytochrome c oxidase subunit VIA-liver; COX VIa-L |
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3D Structure | ||||||
Sequence |
MAVVGVSSVSRLLGRSRPQLGRPMSSGAHGEEGSARMWKTLTFFVALPGVAVSMLNVYLK
SHHGEHERPEFIAYPHLRIRTKPFPWGDGNHTLFHNPHVNPLPTGYEDE |
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Target Bioclass |
Enzyme
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Family |
Cytochrome c oxidase subunit 6A family
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Subcellular location |
Mitochondrion inner membrane
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Function |
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
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Uniprot ID | ||||||
Ensemble ID | ||||||
HGNC ID |
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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5E-2FA Probe Info |
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H95(0.00); H98(0.00) | LDD2235 | [1] | |
m-APA Probe Info |
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H98(0.00); H95(0.00); H63(0.00) | LDD2231 | [1] | |
1c-yne Probe Info |
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N.A. | LDD0228 | [2] | |
Acrolein Probe Info |
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N.A. | LDD0217 | [3] | |
Crotonaldehyde Probe Info |
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N.A. | LDD0219 | [3] | |
Methacrolein Probe Info |
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N.A. | LDD0218 | [3] |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
References