Details of the Target

General Information of Target

Target ID LDTP02597
Target Name Immunoglobulin iota chain (VPREB1)
Gene Name VPREB1
Gene ID 7441
Synonyms
VPREB; Immunoglobulin iota chain; CD179 antigen-like family member A; Protein VPreB1; V(pre)B protein; VpreB protein; CD antigen CD179a
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSWAPVLLMLFVYCTGCGPQPVLHQPPAMSSALGTTIRLTCTLRNDHDIGVYSVYWYQQR
PGHPPRFLLRYFSQSDKSQGPQVPPRFSGSKDVARNRGYLSISELQPEDEAMYYCAMGAR
SSEKEEREREWEEEMEPTAARTRVP
Target Bioclass
Immunoglobulin
Family
Immunoglobulin superfamily
Subcellular location
Endoplasmic reticulum
Function
Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation.
Uniprot ID
P12018
Ensemble ID
ENST00000403807.4
HGNC ID
HGNC:12709

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C115(1.19)  LDD3403  [1]
Acrolein
 Probe Info  		N.A.  LDD0223  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 697 C115(1.82)  LDD2245  [1]
 LDCM0023  KB03 JM-1 C115(1.50)  LDD2825  [1]
 LDCM0024  KB05 Reh C115(1.19)  LDD3403  [1]
 LDCM0109  NEM HeLa N.A.  LDD0223  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.