Details of the Target

General Information of Target

Target ID LDTP02584
Target Name Pulmonary surfactant-associated protein C (SFTPC)
Gene Name SFTPC
Gene ID 6440
Synonyms
SFTP2; Pulmonary surfactant-associated protein C; SP-C; Pulmonary surfactant-associated proteolipid SPL(Val); SP5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDVGSKEVLMESPPDYSAAPRGRFGIPCCPVHLKRLLIVVVVVVLIVVVIVGALLMGLHM
SQKHTEMVLEMSIGAPEAQQRLALSEHLVTTATFSIGSTGLVVYDYQQLLIAYKPAPGTC
CYIMKIAPESIPSLEALTRKVHNFQMECSLQAKPAVPTSKLGQAEGRDAGSAPSGGDPAF
LGMAVSTLCGEVPLYYI
Target Bioclass
Other
Subcellular location
Secreted, extracellular space, surface film
Function Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
Uniprot ID
P11686
Ensemble ID
ENST00000318561.7
HGNC ID
HGNC:10802

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AMP probe
 Probe Info  		N.A.  LDD0200  [1]
ATP probe
 Probe Info  		N.A.  LDD0199  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Serine protease hepsin (HPN) Peptidase S1 family P05981
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cell cycle control protein 50B (TMEM30B) CDC50/LEM3 family Q3MIR4
Claudin-5 (CLDN5) Claudin family O00501
Gap junction alpha-8 protein (GJA8) Connexin family P48165
Protein transport protein Sec61 subunit gamma (SEC61G) SecE/SEC61-gamma family P60059
Transmembrane protein 106C (TMEM106C) TMEM106 family Q9BVX2
Transmembrane protein 139 (TMEM139) . Q8IV31
Transmembrane protein 79 (TMEM79) . Q9BSE2
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Intercellular adhesion molecule 3 (ICAM3) ICAM family P32942
Sialic acid-binding Ig-like lectin 9 (SIGLEC9) SIGLEC (sialic acid binding Ig-like lectin) family Q9Y336
Poliovirus receptor (PVR) Nectin family P15151
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-X-C motif chemokine 9 (CXCL9) Intercrine alpha (chemokine CxC) family Q07325
Interferon gamma receptor 2 (IFNGR2) Type II cytokine receptor family P38484
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Complexin-4 (CPLX4) Complexin/synaphin family Q7Z7G2
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Golgi membrane protein 1 (GOLM1) GOLM family Q8NBJ4
Nesprin-4 (SYNE4) Nesprin family Q8N205
Vesicle-trafficking protein SEC22a (SEC22A) Synaptobrevin family Q96IW7
Fibronectin type III domain-containing protein 9 (FNDC9) . Q8TBE3
Leucine-rich single-pass membrane protein 2 (LSMEM2) . Q8N112
NKG2-A/NKG2-B type II integral membrane protein (KLRC1) . P26715
PDZK1-interacting protein 1 (PDZK1IP1) . Q13113
Pulmonary surfactant-associated protein C (SFTPC) . P11686
Small integral membrane protein 3 (SMIM3) . Q9BZL3

References

1 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.