Details of the Target

General Information of Target

Target ID LDTP02583
Target Name Uteroglobin (SCGB1A1)
Gene Name SCGB1A1
Gene ID 7356
Synonyms
CC10; CCSP; UGB; Uteroglobin; Club cell phospholipid-binding protein; CCPBP; Club cells 10 kDa secretory protein; CC10; Secretoglobin family 1A member 1; Urinary protein 1; UP-1; UP1; Urine protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKLAVTLTLVTLALCCSSASAEICPSFQRVIETLLMDTPSSYEAAMELFSPDQDMREAGA
QLKKLVDTLPQKPRESIIKLMEKIAQSSLCN
Target Type
Literature-reported
Target Bioclass
Cytokine and receptor
Family
Secretoglobin family
Subcellular location
Secreted
Function Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
TTD ID
T93484
Uniprot ID
P11684
DrugMap ID
TTONPVW
Ensemble ID
ENST00000278282.3
HGNC ID
HGNC:12523

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
N1
 Probe Info  		S87(0.00); S88(0.00)  LDD0245  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glycine amidinotransferase, mitochondrial (GATM) Amidinotransferase family P50440
E3 ubiquitin-protein ligase TRIM32 (TRIM32) TRIM/RBCC family Q13049
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein c-Fos (FOS) BZIP family P01100
Heat shock factor protein 1 (HSF1) HSF family Q00613
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane protein 43 (TMEM43) TMEM43 family Q9BTV4
Fibronectin (FN1) . P02751

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
44'-bis([H]Methylsulfonyl)-22'55'-tetrachlorobiphenyl . DB08373

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.