Details of the Target
General Information of Target
| Target ID | LDTP02551 | |||||
|---|---|---|---|---|---|---|
| Target Name | Integrin alpha-M (ITGAM) |
|
||||
| Gene Name | ITGAM | |||||
| Gene ID | 3684 | |||||
| Synonyms |
CD11B; CR3A; Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD antigen CD11b
|
|||||
| 3D Structure | ||||||
| Sequence |
MALRVLLLTALTLCHGFNLDTENAMTFQENARGFGQSVVQLQGSRVVVGAPQEIVAANQR
GSLYQCDYSTGSCEPIRLQVPVEAVNMSLGLSLAATTSPPQLLACGPTVHQTCSENTYVK GLCFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQL KKSKTLFSLMQYSEEFRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFN ITNGARKNAFKILVVITDGEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQEL NTIASKPPRDHVFQVNNFEALKTIQNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAIT SNGPLLSTVGSYDWAGGVFLYTSKEKSTFINMTRVDSDMNDAYLGYAAAIILRNRVQSLV LGAPRYQHIGLVAMFRQNTGMWESNANVKGTQIGAYFGASLCSVDVDSNGSTDLVLIGAP HYYEQTRGGQVSVCPLPRGRARWQCDAVLYGEQGQPWGRFGAALTVLGDVNGDKLTDVAI GAPGEEDNRGAVYLFHGTSGSGISPSHSQRIAGSKLSPRLQYFGQSLSGGQDLTMDGLVD LTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAGEVRVCLHVQKS TRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRRQTQVLGLTQTCETLKLQLPN CIEDPVSPIVLRLNFSLVGTPLSAFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDDL SITFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRSQ RSWRLACESASSTEVSGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKAN VTSENNMPRTNKTEFQLELPVKYAVYMVVTSHGVSTKYLNFTASENTSRVMQHQYQVSNL GQRSLPISLVFLVPVRLNQTVIWDRPQVTFSENLSSTCHTKERLPSHSDFLAELRKAPVV NCSIAVCQRIQCDIPFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFT LLPGQGAFVRSQTETKVEPFEVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKDM MSEGGPPGAEPQ |
|||||
| Target Type |
Clinical trial
|
|||||
| Target Bioclass |
Other
|
|||||
| Family |
Integrin alpha chain family
|
|||||
| Subcellular location |
Cell membrane
|
|||||
| Function |
Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development.
|
|||||
| TTD ID | ||||||
| Uniprot ID | ||||||
| DrugMap ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| 22RV1 | Deletion: p.Q52RfsTer3 | . | |||
| A431 | SNV: p.P765S | DBIA Probe Info | |||
| DU145 | SNV: p.A689S | . | |||
| EFO27 | Deletion: p.H481IfsTer44 | . | |||
| EGI1 | SNV: p.R732H | . | |||
| HEC1 | SNV: p.A756V | . | |||
| HEC1B | SNV: p.A756V | . | |||
| HEP3B217 | Substitution: p.P145N | DBIA Probe Info | |||
| HT115 | SNV: p.F262L; p.V635A; p.E723G | . | |||
| IGR1 | SNV: p.S296F | . | |||
| IGROV1 | SNV: p.L716P | DBIA Probe Info | |||
| JURKAT | SNV: p.Q569H; p.A924T | . | |||
| KPNYN | SNV: p.H428Q | DBIA Probe Info | |||
| MCC13 | SNV: p.N769S | . | |||
| MEWO | SNV: p.Q28Ter | DBIA Probe Info | |||
| NALM6 | SNV: p.G430S | . | |||
| NCIH1793 | SNV: p.Q703H | . | |||
| NCIH1993 | SNV: p.R949L | . | |||
| NCIH2286 | SNV: p.P1103T | . | |||
| NCIH23 | SNV: p.G607R Substitution: p.P578Q |
DBIA Probe Info | |||
| OAW28 | SNV: p.R699L | . | |||
| RKO | Deletion: p.P100LfsTer20 | . | |||
| SHP77 | SNV: p.K830N | . | |||
| SKES1 | Deletion: p.V1020Ter | . | |||
| SW1271 | SNV: p.K1016M | . | |||
| SW837 | SNV: p.V1097G | DBIA Probe Info | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C495(3.07); C722(2.06) | LDD3334 | [1] | |
Competitor(s) Related to This Target