Details of the Target
General Information of Target
| Target ID | LDTP02538 | |||||
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| Target Name | Phenylethanolamine N-methyltransferase (PNMT) | |||||
| Gene Name | PNMT | |||||
| Gene ID | 5409 | |||||
| Synonyms |
PENT; Phenylethanolamine N-methyltransferase; PNMTase; EC 2.1.1.28; Noradrenaline N-methyltransferase |
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| 3D Structure | ||||||
| Sequence |
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGA FNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVS AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVR EALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL |
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| Target Type |
Literature-reported
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| Target Bioclass |
Enzyme
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| Family |
Class I-like SAM-binding methyltransferase superfamily, NNMT/PNMT/TEMT family
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| Function |
Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor. Other substrates include phenylethanolamine and octopamine. Also methylates normetanephrine.
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| TTD ID | ||||||
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Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C139(1.34) | LDD3354 | [1] | |
Competitor(s) Related to This Target