Details of the Target

General Information of Target

Target ID LDTP02530
Target Name Hyaluronan and proteoglycan link protein 1 (HAPLN1)
Gene Name HAPLN1
Gene ID 1404
Synonyms
CRTL1; Hyaluronan and proteoglycan link protein 1; Cartilage-linking protein 1; Cartilage-link protein; Proteoglycan link protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKSLLLLVLISICWADHLSDNYTLDHDRAIHIQAENGPHLLVEAEQAKVFSHRGGNVTLP
CKFYRDPTAFGSGIHKIRIKWTKLTSDYLKEVDVFVSMGYHKKTYGGYQGRVFLKGGSDS
DASLVITDLTLEDYGRYKCEVIEGLEDDTVVVALDLQGVVFPYFPRLGRYNLNFHEAQQA
CLDQDAVIASFDQLYDAWRGGLDWCNAGWLSDGSVQYPITKPREPCGGQNTVPGVRNYGF
WDKDKSRYDVFCFTSNFNGRFYYLIHPTKLTYDEAVQACLNDGAQIAKVGQIFAAWKILG
YDRCDAGWLADGSVRYPISRPRRRCSPTEAAVRFVGFPDKKHKLYGVYCFRAYN
Target Bioclass
Immunoglobulin
Family
HAPLN family
Subcellular location
Secreted, extracellular space, extracellular matrix
Function Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
Uniprot ID
P10915
Ensemble ID
ENST00000274341.9
HGNC ID
HGNC:2380

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C325(1.02)  LDD3387  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2780 C325(2.33); C226(2.70)  LDD2254  [1]
 LDCM0023  KB03 A2780 C325(2.51); C226(2.47)  LDD2671  [1]
 LDCM0024  KB05 OVKATE C325(1.02)  LDD3387  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840