Details of the Target

General Information of Target

Target ID LDTP02519
Target Name T-cell-specific surface glycoprotein CD28 (CD28)
Gene Name CD28
Gene ID 940
Synonyms
T-cell-specific surface glycoprotein CD28; TP44; CD antigen CD28
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLRLLLALNLFPSIQVTGNKILVKQSPMLVAYDNAVNLSCKYSYNLFSREFRASLHKGLD
SAVEVCVVYGNYSQQLQVYSKTGFNCDGKLGNESVTFYLQNLYVNQTDIYFCKIEVMYPP
PYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKPFWVLVVVGGVLACYSLLVTVAFIIFWVR
SKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRS
Target Type
Successful
Target Bioclass
Immunoglobulin
Subcellular location
Membrane; Cell surface
Function
Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells.
TTD ID
T85529
Uniprot ID
P10747
DrugMap ID
TTQ13FT
Ensemble ID
ENST00000324106.9
HGNC ID
HGNC:1653
ChEMBL ID
CHEMBL5191

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT3 SNV: p.R203H .
RL952 SNV: p.V36A .
SUDHL6 SNV: p.N193S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y218(7.33); Y191(6.17)  LDD0260  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) PI3K p85 subunit family P27986

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Belatacept . D0N4HB
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ab-103 Small molecular drug D04HQJ
Phase 2
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Regn5678 Antibody D8UZM7
Au101 . D0T9JW
Lulizumab Pegol . D0GB5X
Phase 1
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sar442257 Antibody DBP9Q5
Cd19-car And Cd28-car T Cells CAR T Cell Therapy (Dual specific) D0QE4F
Cd28 And Cd137 Car-t Cells CAR T Cell Therapy (Dual specific) D0JY0M
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Anti-cd28 Antibody D0V9LF
Fr-104 Antibody D0A2MA
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Tgn-1412 Antibody D00PNU

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853