Details of the Target
General Information of Target
| Target ID | LDTP02498 | |||||
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| Target Name | S-arrestin (SAG) |
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| Gene Name | SAG | |||||
| Gene ID | 6295 | |||||
| Synonyms |
S-arrestin; 48 kDa protein; Retinal S-antigen; S-AG; Rod photoreceptor arrestin |
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| 3D Structure | ||||||
| Sequence |
MAASGKTSKSEPNHVIFKKISRDKSVTIYLGNRDYIDHVSQVQPVDGVVLVDPDLVKGKK
VYVTLTCAFRYGQEDIDVIGLTFRRDLYFSRVQVYPPVGAASTPTKLQESLLKKLGSNTY PFLLTFPDYLPCSVMLQPAPQDSGKSCGVDFEVKAFATDSTDAEEDKIPKKSSVRLLIRK VQHAPLEMGPQPRAEAAWQFFMSDKPLHLAVSLNKEIYFHGEPIPVTVTVTNNTEKTVKK IKAFVEQVANVVLYSSDYYVKPVAMEEAQEKVPPNSTLTKTLTLLPLLANNRERRGIALD GKIKHEDTNLASSTIIKEGIDRTVLGILVSYQIKVKLTVSGFLGELTSSEVATEVPFRLM HPQPEDPAKESYQDANLVFEEFARHNLKDAGEAEEGKRDKNDVDE |
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| Target Bioclass |
Other
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| Family |
Arrestin family
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| Subcellular location |
Cell projection, cilium, photoreceptor outer segment
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| Function |
Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal photoreceptor cells.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C67(4.29) | LDD3338 | [1] | |
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NAIA_5 Probe Info |
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N.A. | LDD2223 | [2] | |
Competitor(s) Related to This Target
References