Details of the Target
General Information of Target
Target ID | LDTP02482 | |||||
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Target Name | Cytochrome c oxidase subunit 8A, mitochondrial (COX8A) | |||||
Gene Name | COX8A | |||||
Gene ID | 1351 | |||||
Synonyms |
COX8; COX8L; Cytochrome c oxidase subunit 8A, mitochondrial; Cytochrome c oxidase polypeptide VIII-liver/heart; Cytochrome c oxidase subunit 8-2 |
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3D Structure | ||||||
Sequence |
MSVLTPLLLRGLTGSARRLPVPRAKIHSLPPEGKLGIMELAVGLTSCFVTFLLPAGWILS
HLETYRRPE |
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Target Bioclass |
Transporter and channel
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Family |
Cytochrome c oxidase VIII family
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Subcellular location |
Mitochondrion inner membrane
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Function |
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
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Uniprot ID | ||||||
Ensemble ID | ||||||
HGNC ID |
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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Acrolein Probe Info |
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N.A. | LDD0217 | [1] | |
Crotonaldehyde Probe Info |
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N.A. | LDD0219 | [1] | |
W1 Probe Info |
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S28(0.00); H27(0.00) | LDD0236 | [2] |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Transcription factor
Protein name | Family | Uniprot ID | |||
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Basic leucine zipper transcriptional factor ATF-like (BATF) | BZIP family | Q16520 |
Other
Protein name | Family | Uniprot ID | |||
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Nucleophosmin (NPM1) | Nucleoplasmin family | P06748 | |||
Epididymal secretory protein E3-beta (EDDM3B) | . | P56851 | |||
Melanoma-associated antigen 4 (MAGEA4) | . | P43358 |
References