Details of the Target
General Information of Target
| Target ID | LDTP02451 | |||||
|---|---|---|---|---|---|---|
| Target Name | EEF1AKMT4-ECE2 readthrough transcript protein (EEF1AKMT4-ECE2) | |||||
| Gene Name | EEF1AKMT4-ECE2 | |||||
| Gene ID | 110599583 | |||||
| Synonyms |
EEF1AKMT4-ECE2 readthrough transcript protein; EC 3.4.24.71) [Includes: Methyltransferase-like region; EC 2.1.1.-; Endothelin-converting enzyme 2 region; EC 3.4.24.71)] |
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| 3D Structure | ||||||
| Sequence |
MASPGAGRAPPELPERNCGYREVEYWDQRYQGAADSAPYDWFGDFSSFRALLEPELRPED
RILVLGCGNSALSYELFLGGFPNVTSVDYSSVVVAAMQARHAHVPQLRWETMDVRKLDFP SASFDVVLEKGTLDALLAGERDPWTVSSEGVHTVDQVLSEVGFQKGTRQLLGSRTQLELV LAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSPCEDFYQ FSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCL QVERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYISADSK SSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQV LELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPV VVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKS CVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQLVWMDE KTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMAD QLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGH ELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGE NIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGL VTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW |
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| Target Bioclass |
Enzyme
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| Family |
Methyltransferase superfamily; Peptidase M13 family
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| Subcellular location |
Golgi apparatus membrane
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| Function | Converts big endothelin-1 to endothelin-1. May also have methyltransferase activity. May play a role in amyloid-beta processing. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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HHS-465 Probe Info |
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N.A. | LDD2240 | [1] | |