Details of the Target

General Information of Target

Target ID LDTP02427
Target Name Protein SETSIP (SETSIP)
Gene Name SETSIP
Gene ID 646817
Synonyms
SETP18; Protein SETSIP; SET pseudogene protein 18; SET similar protein; Similar to SET translocation protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MVWFLDFPNSMAPKRQSPLPLQKKKPRPPPALGLEETSASAGLPKKGEKEQQEAIEHIDE
VQNEIDRLNEQDSEEILKVEQKYNKLRQPFFQKRSELIAKIPNFGVTTFVNHPQVSSLLG
EEDEEALHYLTKVEVTEFEDIKSGYRIDFYFDENPYFENKVFSKEFHLNESGDPSSKSTK
IKWKSGKDVTKRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGADELEEVIKDDIWPNPL
QYYLVPDMDDEEGGEDDDDDDDDGDEGEEELEDIDEGDEDEGEEDEDDDEGEEGEEDEGE
DD
Target Bioclass
Other
Family
Nucleosome assembly protein (NAP) family
Subcellular location
Cytoplasm
Function
Plays a role as a transcriptional activator involved in the early stage of somatic cell reprogramming. Promotes the differentiation of protein-induced pluripotent stem (PiPS) cells into endothelial cells and the formation of vascular-like tubes (in vitro). Involved in the transcription induction of vascular endothelial-cadherin (VE-cadherin) expression. Associates to the VE-cadherin gene promoter.
Uniprot ID
P0DME0
Ensemble ID
ENST00000596516.3
HGNC ID
HGNC:42937

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		E139(0.88); E165(1.01); E134(0.97); D173(0.92)  LDD2208  [1]
HHS-475
 Probe Info  		Y150(0.91); Y83(0.99)  LDD0264  [2]
m-APA
 Probe Info  		N.A.  LDD2231  [3]
HHS-465
 Probe Info  		K199(0.00); K82(0.00); Y83(0.00); Y145(0.00)  LDD2240  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y150(0.91); Y83(0.99)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y83(1.00); Y150(1.18)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y150(0.95); Y83(1.04)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y150(0.85); Y83(0.96)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y150(0.96); Y83(1.00)  LDD0268  [2]

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010