Details of the Target

General Information of Target

Target ID LDTP02418
Target Name RNA-binding motif protein, Y chromosome, family 1 member A1 (RBMY1A1)
Gene Name RBMY1A1
Gene ID 5940
Synonyms
RBM1; RBM2; YRRM1; YRRM2; RNA-binding motif protein, Y chromosome, family 1 member A1; RNA-binding motif protein 1; RNA-binding motif protein 2; Y chromosome RNA recognition motif 1; hRBMY
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRTSKSRGFAFITFENPAD
AKNAAKDMNGKSLHGKAIKVEQAKKPSFQSGGRRRPPASSRNRSPSGSLRSARGSRGGTR
GWLPSHEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARSNSWMGS
QGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATNDGNHPSCQETRDYAPPSRGYAY
RDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSRGYRNRRSSR
ETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPSSRETRDYAPPHRDYAYRDYGHSSWD
EHSSRGYSYHDGYGEALGRDHSEHLSGSSYRDALQRYGTSHGAPPARGPRMSYGGSTCHA
YSNTRDRYGRSWESYSSCGDFHYCDREHVCRKDQRNPPSLGRVLPDPREACGSSSYVASI
VDGGESRSEKGDSSRY
Target Bioclass
Other
Subcellular location
Nucleus
Function
RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs.
Uniprot ID
P0DJD3
Ensemble ID
ENST00000382707.6
HGNC ID
HGNC:9912

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
N1
 Probe Info  		H74(0.00); K76(0.00); K79(0.00)  LDD0245  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) Cytidine and deoxycytidylate deaminase family Q9NRW3
Putative ATP-dependent RNA helicase DHX57 (DHX57) DEAD box helicase family Q6P158
Dual specificity protein kinase CLK3 (CLK3) CMGC Ser/Thr protein kinase family P49761
Dexamethasone-induced Ras-related protein 1 (RASD1) RasD family Q9Y272
Apoptosis-enhancing nuclease (AEN) . Q8WTP8
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 317 (ZNF317) Krueppel C2H2-type zinc-finger protein family Q96PQ6
Myb-related transcription factor, partner of profilin (MYPOP) . Q86VE0
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hemoglobin subunit zeta (HBZ) Globin family P02008
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
U1 small nuclear ribonucleoprotein A (SNRPA) RRM U1 A/B'' family P09012
Chromobox protein homolog 2 (CBX2) . Q14781
Cold-inducible RNA-binding protein (CIRBP) . Q14011
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) . P61978
Lamin tail domain-containing protein 2 (LMNTD2) . Q8IXW0
Proline-rich protein 3 (PRR3) . P79522
Protocadherin beta-14 (PCDHB14) . Q9Y5E9
RNA-binding motif protein, X chromosome (RBMX) . P38159
RNA-binding motif protein, Y chromosome, family 1 member F/J (RBMY1F; RBMY1J) . Q15415
RNA-binding protein 3 (RBM3) . P98179
Telomeric repeat-binding factor 1 (TERF1) . P54274
YTH domain-containing protein 1 (YTHDC1) . Q96MU7

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.