Details of the Target
General Information of Target
| Target ID | LDTP02405 | |||||
|---|---|---|---|---|---|---|
| Target Name | Myocardial zonula adherens protein (MYZAP) | |||||
| Gene Name | MYZAP | |||||
| Gene ID | 100820829 | |||||
| Synonyms |
MYOZAP; Myocardial zonula adherens protein; GRINL1A upstream protein; Gup |
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| 3D Structure | ||||||
| Sequence |
MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN
GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV HCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE VETREIGVGCDLLPSQTGRTREIVMPSRNYTPYTRVLELTMKKTLT |
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| Target Bioclass |
Enzyme
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| Family |
MYZAP family
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| Subcellular location |
Cytoplasm, cytoskeleton
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| Function |
Plays a role in cellular signaling via Rho-related GTP-binding proteins and subsequent activation of transcription factor SRF. Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| 22RV1 | SNV: p.Y122C | . | |||
| HT | SNV: p.E372D | . | |||
| KELLY | SNV: p.V41A | DBIA Probe Info | |||
| KMS11 | SNV: p.Y122Ter | DBIA Probe Info | |||
| KYSE410 | SNV: p.E294G | . | |||
| MFE319 | SNV: p.D158G | DBIA Probe Info | |||
| MSTO211H | Substitution: p.A168V | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C447(1.17) | LDD3318 | [1] | |
Competitor(s) Related to This Target